Stem Cell Studies
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Condition

Knee osteoarthritis

We found and sorted 1,249 published studies of stem cell and regenerative treatments for knee osteoarthritis. 581 of them treated or observed patients, and 200 of those were randomized controlled trials.

The evidence ladder

Every study gets one label for the kind of study it is. Study types near the top of the list generally give more reliable answers about whether a treatment works in people.

  1. 200Randomized controlled trials16%
  2. 121Controlled studies10%
  3. 260Case series21%
  4. 185Animal or lab studies15%
  5. 483Reviews39%

Studies published each year

  • Randomized controlled trials
  • Controlled studies
  • Case series
  • Animal or lab studies
  • Reviews
050100150200200320052010201520202025

Hover or tab across the columns for each year's numbers.

Show as a table
YearRandomized controlled trialsControlled studiesCase seriesAnimal or lab studiesReviews
20261313312265
20252218282293
20242713212859
20231613321643
20223113251753
20211912301847
2020149201633
2019138181130
201817410621
20177210713
2016921238
201565438
201412437
201331853
201224240
201100310
201001200
200900010
200801000
200700000
200600000
200500000
200400010
200300010

The most recent year is incomplete. Counts cover studies indexed in PubMed in English with a published summary.

What was given to patients

Across 512 of the 581 studies in patients, by where the cells or blood product came from. The rest are waiting for a person to check.

Largest registered trials

From ClinicalTrials.gov, by number of participants. 292 trials are registered in total. A registered trial has not necessarily published results.

Ten largest registered trials
TrialParticipantsDesignStatus
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the KneeNCT02844751 · VivaTech International, Inc.4,000 plannedNot randomizedPhase 2Recruiting
The Knee Usual Care Evaluation StudyNCT01905358 · Hospital for Special Surgery, New York906Single group or not statedNo phase listedTerminated
A Study to Investigate the Effectiveness, Safety, and Tolerability of MAG200 Solution for Intra-articular Injection Compared With Placebo in Participants Aged 35 to 75 Years of Age With Symptomatic Osteoarthritis of the Knee.NCT07106229 · Magellan Stem Cells573 plannedRandomizedPhase 3Not yet recruiting
Comparison of Acetaminophen and PRP Therapy for Knee OANCT01782885 · Hospital Universitario Dr. Jose E. Gonzalez543RandomizedNACompleted
Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Knee OsteoarthritisNCT06570291 · Wuxi Cellular Biopharmaceutical Group Ltd.520 plannedRandomizedPhase 3Recruiting
Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES)NCT03818737 · Emory University475RandomizedPhase 3Completed
Efficacy and Safety of IxCell hUC-MSC-O in Patients With Knee OsteoarthritisNCT06716281 · Shanghai IxCell Biotechnology Co., LTD398 plannedRandomizedPhase 3Recruiting
Bone Marrow Aspirate Concentrate (BMAC) Treatment for Knee OsteoarthritisNCT06216028 · CELL Technologies Inc.374 plannedRandomizedPhase 3Not yet recruiting
Platelet Rich Plasma Injection for Knee OsteoarthritisNCT04454164 · Ferhat Say324RandomizedEarly Phase 1Completed
Clinical Investigation to Compare the Safety and Efficacy of Cellular Matrix to Those of Ostenil® Plus and to Those of PRP OnlyNCT02964143 · Regen Lab SA306 plannedRandomizedNAStatus unknown

Trials open now

48 registered trials list themselves as recruiting or about to recruit. We do not recommend or vet trials or clinics. Listing here is not an endorsement.

Trials open to enrollment
TrialParticipantsDesignStatus
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the KneeNCT02844751 · VivaTech International, Inc.4,000 plannedNot randomizedPhase 2Recruiting
A Study to Investigate the Effectiveness, Safety, and Tolerability of MAG200 Solution for Intra-articular Injection Compared With Placebo in Participants Aged 35 to 75 Years of Age With Symptomatic Osteoarthritis of the Knee.NCT07106229 · Magellan Stem Cells573 plannedRandomizedPhase 3Not yet recruiting
Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Knee OsteoarthritisNCT06570291 · Wuxi Cellular Biopharmaceutical Group Ltd.520 plannedRandomizedPhase 3Recruiting
Efficacy and Safety of IxCell hUC-MSC-O in Patients With Knee OsteoarthritisNCT06716281 · Shanghai IxCell Biotechnology Co., LTD398 plannedRandomizedPhase 3Recruiting
Bone Marrow Aspirate Concentrate (BMAC) Treatment for Knee OsteoarthritisNCT06216028 · CELL Technologies Inc.374 plannedRandomizedPhase 3Not yet recruiting
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and OsteoarthritisNCT07339111 · Medipost, Inc.300 plannedRandomizedPhase 3Recruiting
Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal ConditionsNCT06000670 · Dubai Health Authority300 plannedSingle group or not statedNANot yet recruiting
IDENTIFICATION OF BIOMARKERS ASSOCIATED WITH THE SEVERITY AND RADIO-CLINICAL PROGRESSION OF KNEE OSTEOARTHRITISNCT06600958 · Assistance Publique - Hôpitaux de Paris300 plannedSingle group or not statedNo phase listedRecruiting
Combined Use of PRP and Hyaluronic Acid for Infiltrative Treatment of Patients With Knee OsteoarthritisNCT06685120 · Istituto Ortopedico Rizzoli288 plannedRandomizedNARecruiting
Platelet-rich Plasma in Symptomatic Knee OsteoarthritisNCT05378815 · Assistance Publique - Hôpitaux de Paris210 plannedRandomizedNARecruiting
Bone Marrow Versus Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee OsteoarthritisNCT06040957 · Istituto Ortopedico Rizzoli204 plannedRandomizedNARecruiting
Comparison Between Intra-articular Infiltrations of PRP, MFAT, and PRP-MFAT in the Treatment of Symptomatic Knee Osteoarthritis.NCT06084637 · Assistance Publique Hopitaux De Marseille180 plannedRandomizedPhase 3Not yet recruiting
A Study of NCR100 Injection for the Treatment of Knee Osteoarthritis（ KOA）NCT06741098 · Nuwacell Biotechnologies Co., Ltd.162 plannedRandomizedPhase 1 / Phase 2Not yet recruiting
Orthobiologic Treatment for Knee OsteoarthritisNCT06893250 · University Hospital of North Norway160 plannedRandomizedPhase 2 / Phase 3By invitation
Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosisNCT07016672 · Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer150 plannedRandomizedNARecruiting
Implantation of Engineered Cartilage Grafts for Treatment of Patellofemoral Osteoarthritis Versus Surgical Comparators.NCT06576583 · University Hospital, Basel, Switzerland150 plannedRandomizedPhase 2Recruiting
Comparison of Effectiveness Between PL and PRP on Knee Osteoarthritis: a Prospective,Randomized,Placebo-controlled TrialNCT03734900 · National Taiwan University Hospital150 plannedRandomizedPhase 4Recruiting
Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OANCT05517434 · University Health Network, Toronto148 plannedRandomizedPhase 2 / Phase 3Recruiting
An Open-Label, Double-Treatment Group Study to Evaluate the Efficacy and Safety of Human Allogeneic Bone-Marrow- Derived Mesenchymal Stromal Cell Product StromaForte Compared With Hyaluronic Acid for the Treatment of Knee OsteoarthritisNCT07542808 · Cellcolabs Clinical SPV Limited140 plannedNot randomizedPhase 2 / Phase 3Recruiting
Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee OsteoarthritisNCT07617233 · Utku Gürhan120 plannedSingle group or not statedNo phase listedNot yet recruiting
Effectiveness of Stromal Vascular Fraction (SVF) and Platelet -Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study.NCT05660824 · Adrien Schwitzguebel108 plannedRandomizedPhase 4Not yet recruiting
Treatment of Symptomatic Bilateral Knee Osteoarthritis: Intra-articular Injection of Autologous Microfragmented Adipose Tissue and Hyaluronic Acid vs Intra Articular Injection of Autologous Microfragmented Adipose TissueNCT07121556 · Istituto Ortopedico Rizzoli100 plannedRandomizedNARecruiting
Efficacy at One Year of Combined Injections of Plasma Rich in Platelets and Hyaluronic Acid in Knee OsteoarthritisNCT05039463 · Centre Hospitalier Universitaire, Amiens100 plannedSingle group or not statedNo phase listedRecruiting
Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee OsteoarthritisNCT03491761 · Endeavor Health100 plannedRandomizedPhase 2Recruiting
Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid InjectionNCT05985785 · Rush University Medical Center100 plannedRandomizedNARecruiting
Efficacy of Platelet-Rich Plasma Combined With Hyaluronic Acid in Knee OsteoarthritisNCT07784907 · Implai Sp z o.o100 plannedRandomizedNARecruiting
Treatment of Knee Osteoarthritis With Bone Marrow Aspirate Matrix: Prospective, Randomized TrialNCT06238934 · Instituto Nacional de Traumatologia e Ortopedia90 plannedRandomizedPhase 3Not yet recruiting
Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee OsteoarthritisNCT07766330 · Federal University of São Paulo90 plannedRandomizedNANot yet recruiting
Comparing the Efficacy of Lyophilized Self Growth Factor Versus PRP Injection for Knee OANCT06932614 · Tri-Service General Hospital (TSGH)90 plannedSingle group or not statedNARecruiting
Allogenic Mesenchymal Stem Cell Intraarticular Injection for Knee Osteoarthritis TherapyNCT05933434 · Aarhus University Hospital80 plannedRandomizedPhase 1 / Phase 2Recruiting
Treatment of Patellofemoral Osteoarthritis With Engineered Cartilage.NCT06163573 · University Hospital, Basel, Switzerland75 plannedRandomizedPhase 2Recruiting
The Safety and Efficacy of XytriX (Umbilical Cord-Derived Mesenchymal Stem Cells) in the Treatment of Knee OsteoarthritisNCT07487766 · TricelX Inc.75 plannedRandomizedPhase 1 / Phase 2Not yet recruiting
Effects of Steroid, Dextrose Prolotherapy, and Platelet-Rich Plasma Injections in Knee Joint OA PatientsNCT07243392 · Lincoln University College72 plannedRandomizedNANot yet recruiting
Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoarthritis. (KOA PRP ACS)NCT07473232 · Pamukkale University60 plannedRandomizedNARecruiting
Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee OsteoarthritisNCT07329361 · MiKS Hospital60 plannedRandomizedNARecruiting
Efficacy of Platelet-Rich Plasma Added to Hyaluronic Acid in Knee OsteoarthritisNCT07785401 · Implai Sp z o.o50 plannedRandomizedNARecruiting
Phase II/III Randomized Trial of UC-MSC Secretome vs Sodium Hyaluronate in Knee OsteoarthritisNCT07337863 · Universitas Sriwijaya50 plannedRandomizedPhase 2 / Phase 3Not yet recruiting
Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich PlasmaNCT06520059 · Universidade do Porto50 plannedNot randomizedPhase 4Not yet recruiting
The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee OsteoarthritisNCT07339137 · Ankara City Hospital Bilkent42 plannedRandomizedNARecruiting
A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis Patients Who Received Placebo in the K0701 Phase 2a TrialNCT07754175 · Kang Stem Biotech Co., Ltd.36 plannedSingle group or not statedNo phase listedRecruiting
Homologus PRP in the Infiltrative Treatment of Knee Osteoarthritis in Young Athletic PatientsNCT06483269 · Istituto Ortopedico Rizzoli30 plannedSingle group or not statedNARecruiting
Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee OsteoarthritisNCT07157891 · University of the Punjab25 plannedRandomizedEarly Phase 1Not yet recruiting
Safety and Tolerability of StroMel™ in Subjects with Moderate to Severe Osteoarthritis of the Knee JointNCT04750252 · Akan Biosciences, LLC20 plannedSingle group or not statedPhase 1 / Phase 2Not yet recruiting
Phase I Clinical Trial of UC-MSCs in the Treatment of Knee OsteoarthritisNCT06463847 · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology18 plannedNot randomizedPhase 1Recruiting
Follow-up Study for Participants of Jointstem Investigator Initiated Trial by ArthroscopyNCT04825730 · R-Bio14 plannedSingle group or not statedNANot yet recruiting
The Use of Stromal Vascular Fraction for Knee ArthrosisNCT06171204 · University Hospital, Ghent10 plannedSingle group or not statedNARecruiting
Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee OsteoarthritisNCT04716803 · University of California, San Diego10 plannedSingle group or not statedNARecruiting
Handheld MPI Imaging to Track Stem Cells in OsteoarthritisNCT07313020 · Soochow University10 plannedRandomizedEarly Phase 1By invitation

The randomized controlled trials

All 200 published so far, newest first. Each links to its PubMed record.

  1. Comparative efficacy of ultrasound-guided intra-articular injection of platelet-rich plasma (PRP), hydrolyzed type I collagen, and hyaluronic acid in patients with knee osteoarthritis: a randomized controlled trial.Future science OA · 2026 · More than one source · reports side effects
  2. Comparative Efficacy of Intra-Articular Growth Factor Concentrate and Platelet-Rich Plasma Injections in Knee Osteoarthritis: An Evaluation of Clinical, Radiological, and Biomarker Outcomes.Journal of orthopaedic case reports · 2026 · More than one source
  3. The Effect of Intraarticular Platelet-Rich Plasma Injection in Knee Osteoarthritis.Journal of orthopaedic case reports · 2026 · Platelet-rich plasma
  4. Cord Blood-Derived Versus Homologous Donor Platelet-Rich Plasma (PRP) in Early Knee Osteoarthritis: A Single-Center, Randomized, Double-Blind Pilot Clinical Trial.Bioengineering (Basel, Switzerland) · 2026 · More than one source · reports side effects
  5. Ultrasound-Guided Aspiration of Baker's Cyst Combined With Intracystic Platelet-Rich Plasma Injection in Knee Osteoarthritis: A Randomized Controlled Trial.American journal of physical medicine & rehabilitation · 2026 · Platelet-rich plasma
  6. Intra-articular platelet-rich plasma demonstrates superior clinical and serum biomarker outcomes compared with corticosteroids and NSAIDs in late-stage knee osteoarthritis: a randomised controlled trial.Journal of orthopaedic surgery and research · 2026 · Platelet-rich plasma · reports side effects
  7. Clinical efficacy analysis of platelet-rich plasma combined with Xianling Gubao Capsules in the treatment of early-middle stage knee osteoarthritis.Frontiers in medicine · 2026 · Platelet-rich plasma · reports side effects
  8. Randomized clinical trial comparing intra-articular injection of bone marrow aspirate clot and bone marrow aspirate concentrate in grade 3 and 4 knee osteoarthritis.Stem cell research & therapy · 2026 · Bone marrow · reports side effects
  9. Intra-articular allogeneic adipose-derived mesenchymal stromal cell injections for stage III knee osteoarthritis: a double-blind placebo-controlled trial with 60-month follow-up.Stem cells translational medicine · 2026 · Fat (adipose) tissue · reports side effects
  10. Adding microfracture to an SVF-based arthroscopic pathway was associated with greater 24-month improvements in pain, function and MRI cartilage morphology in KL II-III knee osteoarthritis: A randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026 · Fat (adipose) tissue
  11. Efficacy and safety of a combination of platelet-rich plasma with non-crosslinked hyaluronic acid versus a crosslinked hyaluronic acid, in single-injection for knee osteoarthritis. Randomized, controlled, multicenter, non-inferiority trial.BMC musculoskeletal disorders · 2026 · Platelet-rich plasma
  12. A comparative study of the efficacy of single and double centrifuged platelet-rich plasma and placebo (normal saline injection) on pain, ROM, and physical function of patients with knee osteoarthritis: a double-blinded controlled randomized trial with a six-month follow-up.Advances in rheumatology (London, England) · 2026 · Platelet-rich plasma
  13. Cartilage organoids bridging bench to bedside: A steroid-free strategy for early osteoarthritis repair.Materials today. Bio · 2026 · Bone marrow
  14. Intra-articular injection of umbilical cord-derived mesenchymal stem cells is safe and effective for moderate to severe knee osteoarthritis with synovitis: a double‑blinded and randomized controlled trial.BMC musculoskeletal disorders · 2025 · Umbilical cord and birth tissue · reports side effects
  15. Plasma Rich in Growth Factors (PRGF) Versus Saline Intraosseous Infiltrations Combined with Intra-Articular PRGF in Severe Knee Osteoarthritis: A Prospective Double-Blind Multicentric Randomized Controlled Trial with 1-Year Follow-Up.Journal of clinical medicine · 2025 · Platelet-rich plasma · reports side effects
  16. MRI Findings after Injection of Single and Double Centrifuged Platelet-Rich Plasma and Placebo (Normal Saline) in Patients with Knee Osteoarthritis: A Randomized Double-Blind Clinical Trial with Six-Month Follow-Up.The archives of bone and joint surgery · 2025 · Platelet-rich plasma
  17. A randomised controlled trial confirms the non-superiority of bone marrow aspirate (BMA) from the posterior iliac crest and proximal tibia compared to platelet rich plasma (PRP) in the treatment of knee osteoarthritis.Journal of experimental orthopaedics · 2025 · More than one source
  18. Autologous Cell Injections for Knee Osteoarthritis Display Greater Responsiveness Than Allogenic Cellular Products and Corticosteroids in a Sex-Dependent Manner.The American journal of sports medicine · 2025 · More than one source
  19. Clinical and dGEMRIC Evaluation of Microfragmented Adipose Tissue Versus Hyaluronic Acid in Inflammatory Phenotype of Knee Osteoarthritis: A Randomized Controlled Trial.Biomedicines · 2025 · Fat (adipose) tissue
  20. Cartilage Regeneration Potential in Early Osteoarthritis of the Knee: A Prospective, Randomized, Open, and Blinded Endpoint Study Comparing Adipose-Derived Mesenchymal Stem Cell (ADSC) Therapy Versus Hyaluronic Acid.International journal of molecular sciences · 2025 · Fat (adipose) tissue · reports side effects
  21. Effect of intra-articular adipose-derived mesenchymal stromal cell versus placebo injection on pain and function in patients with knee osteoarthritis: the ADIPOA2 phase 2b randomised clinical trial.Annals of the rheumatic diseases · 2025 · Fat (adipose) tissue
  22. Intraarticular injection of the stromal vascular fraction for the treatment of knee osteoarthritis a prospective randomized controlled clinical trial.Scientific reports · 2025 · Fat (adipose) tissue · reports side effects
  23. The comparative effects of injecting intra-articular platelet-rich plasma and hypertonic dextrose prolotherapy in osteoarthritis knee - A randomized control trial.Journal of family medicine and primary care · 2025 · Platelet-rich plasma
  24. Effects of Intra-articular Bone Marrow Aspirate Infiltration in the Treatment of Knee Osteoarthritis: A Clinical Study Comparing BMA versus Corticosteroid and Genicular Block.Revista brasileira de ortopedia · 2025 · Bone marrow
  25. Safety and Efficacy of Platelet-Rich Plasma versus Genicular Nerve Radiofrequency Ablation in Knee Osteoarthritis: An Open-Label, Prospective, Randomized, Clinical Trial.Pain physician · 2025 · Platelet-rich plasma · reports side effects
  26. Clinical Efficacy of Platelet-Rich Plasma and Hyaluronic Acid Versus Hyaluronic Acid for Knee Osteoarthritis with MRI Analysis: A Randomized Controlled Trial.Journal of clinical medicine · 2025 · Platelet-rich plasma
  27. The role of adipose-derived stem cells in knee osteoarthritis treatment: insights from a triple-blind clinical study.Stem cell research & therapy · 2025 · Fat (adipose) tissue
  28. The Multiple Dosing Effects of Platelet-Rich Plasma on Cartilage Regeneration in Knee Osteoarthritis: Randomised, Placebo-Controlled Trial.Malaysian orthopaedic journal · 2025 · Platelet-rich plasma
  29. Cartilage Regeneration Potential of Platelet-Rich Plasma versus Plasma Rich in Growth Factors in Knee Osteoarthritis Based on Serum Biomarker of Cartilage Degradation, Coll2-1: A Triple-Blind Randomized Study.Journal of orthopaedic case reports · 2025 · Platelet-rich plasma
  30. Treatment of knee osteoarthritis with a single injection of autologous micro-fragmented adipose tissue is not superior to a placebo saline injection: a blinded randomised controlled trial with 2-year follow-up.British journal of sports medicine · 2025 · Fat (adipose) tissue
  31. Platelet-Rich Plasma Injections Are Inferior to Corticosteroid Injections for Short-Term Pain Relief: A Prospective, Double-Blinded, Randomized Controlled Trial.The Journal of arthroplasty · 2025 · Platelet-rich plasma
  32. Intra-Articular Injection of Human Bone Marrow-Derived Mesenchymal Stem Cells in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial.Cell transplantation · 2025 · Bone marrow · reports side effects
  33. Impact of Resistance Exercise and Nitrate Supplementation on Muscle Function and Clinical Outcomes After Knee Osteoarthritis Surgery in Middle-Aged Women with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Journal of clinical medicine · 2025 · Source not stated
  34. Effects of Ultrasound-Guided Corticosteroid Injection Compared to Mesenchymal Stem Cell Injection in Patients With Grade II and III Knee Osteoarthritis: A Randomized Double-Blind Controlled Trial.American journal of physical medicine & rehabilitation · 2025 · Source not stated · reports side effects
  35. Efficacy of a single dose of cryopreserved human umbilical cord mesenchymal stromal cells for the treatment of knee osteoarthritis:a randomized, controlled, double-blind pilot study.Cytotherapy · 2025 · Umbilical cord and birth tissue · reports side effects
  36. Effects of muscle energy technique along conventional physical therapy after mesenchymal stem cell transplantation in knee osteoarthritis patients.Pakistan journal of medical sciences · 2024 · Source not stated
  37. Posterior iliac crest vs. proximal tibia: distinct sources of anti-inflammatory and regenerative cells with comparable 6-month clinical outcomes in treatment of osteoarthritis.Journal of translational medicine · 2024 · Bone marrow
  38. Clinical outcomes of autologous adipose-derived mesenchymal stem cell combined with high tibial osteotomy for knee osteoarthritis are correlated with stem cell stemness and senescence.Journal of translational medicine · 2024 · Fat (adipose) tissue
  39. Autologous platelet rich plasma injection can be effective in the management of osteoarthritis of the knee: impact on IL-1 β, TNF-α, hs-CRP.Journal of orthopaedic surgery and research · 2024 · Platelet-rich plasma
  40. Safety and efficacy of placental mesenchymal stromal cells-derived extracellular vesicles in knee osteoarthritis: a randomized, triple-blind, placebo-controlled clinical trial.BMC musculoskeletal disorders · 2024 · Umbilical cord and birth tissue · reports side effects
  41. Evaluating Synergistic Effects of Hyaluronic Acid, Human Umbilical Cord-Derived Mesenchymal Stem Cells, and Growth Hormones in Knee Osteoarthritis: A Multi-Arm Randomized Trial.Biomedicines · 2024 · Umbilical cord and birth tissue
  42. Comparison of the short-term effect of intra-articular hyaluronic acid and platelet-rich plasma injections in knee osteoarthritis: a randomized clinical trial.Journal of preventive medicine and hygiene · 2024 · Platelet-rich plasma · reports side effects
  43. Leukocytes Do Not Influence the Safety and Efficacy of Platelet-Rich Plasma Injections for the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Controlled Trial.The American journal of sports medicine · 2024 · Platelet-rich plasma · reports side effects
  44. Efficacy of intra-articular injection of combined platelet-rich-plasma (PRP) and hyaluronic acid (HA) in knee degenerative joint disease: a prospective, randomized, double-blind clinical trial.Archives of orthopaedic and trauma surgery · 2024 · Platelet-rich plasma · reports side effects
  45. The Effectiveness of Alpha-2-Macroglobulin Injections for Osteoarthritis of the Knee.Bulletin of the Hospital for Joint Disease (2013) · 2024 · Platelet-rich plasma
  46. The combined application of pulsed electromagnetic fields and platelet-rich plasma in the treatment of early-stage knee osteoarthritis: A randomized clinical trial.Medicine · 2024 · Platelet-rich plasma · reports side effects
  47. Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial.Osteoarthritis and cartilage open · 2024 · Fat (adipose) tissue · reports side effects
  48. Evaluation of orthobiological ozonized platelet-rich plasma therapy post-arthroscopic suturing and lone partial meniscectomy in the treatment of meniscal tears within degenerative knee osteoarthritis.The Knee · 2024 · Platelet-rich plasma · reports side effects
  49. The Effectiveness of Leukocyte-Poor Platelet-Rich Plasma Injections for Symptomatic Mild to Moderate Osteoarthritis of the Knee With Joint Effusion or Bone Marrow Lesions in a Japanese Population: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.The American journal of sports medicine · 2024 · Platelet-rich plasma
  50. Is There a Need for an Exogenous Activator Along with PRP for Early Knee Osteoarthritis? A Triple-Blinded Randomized Control Trial.Indian journal of orthopaedics · 2024 · Platelet-rich plasma
  51. The Efficacy of Intra-articular Platelet-Rich Plasma Injection Versus Corticosteroid Injection in the Treatment of Knee Osteoarthritis: A Prospective Comparative Analysis.Cureus · 2024 · Platelet-rich plasma
  52. Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2 years follow-up.World journal of orthopedics · 2024 · Fat (adipose) tissue
  53. The varying clinical effectiveness of single, three and five intraarticular injections of platelet-rich plasma in knee osteoarthritis.Journal of orthopaedic surgery and research · 2024 · Platelet-rich plasma · reports side effects
  54. Allogeneic platelet-rich plasma for knee osteoarthritis in patients with primary immune thrombocytopenia: A randomized clinical trial.iScience · 2024 · Platelet-rich plasma
  55. Relationship of Body Mass Index on Patient-Reported Outcomes After Platelet-Rich Plasma Versus Microfragmented Adipose Tissue for Knee Osteoarthritis: A Secondary Analysis of a Randomized Controlled Trial.American journal of physical medicine & rehabilitation · 2024 · More than one source
  56. Microfragmented Adipose Tissue Is Equivalent to Platelet-Rich Plasma for Knee Osteoarthritis at 12 Months Posttreatment: A Randomized Controlled Trial.Orthopaedic journal of sports medicine · 2024 · More than one source
  57. Morphological and Quantitative Parametric MRI Follow-up of Cartilage Changes Before and After Intra-articular Injection Therapy in Patients With Mild to Moderate Knee Osteoarthritis: A Randomized, Placebo-Controlled Trial.Investigative radiology · 2024 · Platelet-rich plasma
  58. Comparison of Conventional Dose Versus Superdose Platelet-Rich Plasma for Knee Osteoarthritis: A Prospective, Triple-Blind, Randomized Clinical Trial.Orthopaedic journal of sports medicine · 2024 · Platelet-rich plasma · reports side effects
  59. Clinical Outcome of Multiple Platelet-Rich Plasma Injection and Correlation with PDGF-BB in the Treatment of Knee Osteoarthritis.Journal of personalized medicine · 2024 · Platelet-rich plasma
  60. Does the Combination of Platelet-rich Plasma and Supervised Exercise Yield Better Pain Relief and Enhanced Function in Knee Osteoarthritis? A Randomized Controlled Trial.Clinical orthopaedics and related research · 2024 · Platelet-rich plasma
  61. Multiple intra-articular injections of autologous stromal vascular fractions for the treatment of multicompartmental osteoarthritis in both the tibiofemoral and patellofemoral joint: a single-blind randomized controlled study.Postgraduate medical journal · 2024 · Fat (adipose) tissue
  62. Supervised exercises have superior effects compared to home-based exercises for patients with knee osteoarthritis following platelet-rich plasma injection.Research in sports medicine (Print) · 2024 · Platelet-rich plasma
  63. Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial.World journal of stem cells · 2023 · Fat (adipose) tissue · reports side effects
  64. Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial.Nature medicine · 2023 · More than one source · reports side effects
  65. Impact of autologous platelet-rich plasma therapy vs. hyaluronic acid on synovial fluid biomarkers in knee osteoarthritis: a randomized controlled clinical trial.Frontiers in medicine · 2023 · Platelet-rich plasma
  66. Clinical Outcome of Minimally Manipulated, Mechanically Isolated Autologous Adipose Tissue-Derived Stromal Vascular Fraction (Sahaj Therapy®) in Knee Osteoarthritis-Randomized Controlled Trial.Indian journal of orthopaedics · 2023 · Fat (adipose) tissue
  67. Clinical and Biochemical Correlation of Intra-articular Platelet-Rich Plasma and Corticosteroid Using Serum Matrix Metalloproteinase 3 (MMP-3) Levels in Osteoarthritis of Knee.Cureus · 2023 · Platelet-rich plasma
  68. Efficacy and Safety of Stempeucel in Osteoarthritis of the Knee: A Phase 3 Randomized, Double-Blind, Multicenter, Placebo-Controlled Study.The American journal of sports medicine · 2023 · Bone marrow · reports side effects
  69. Clinical Efficacy and Safety of the Intra-articular Injection of Autologous Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial.The American journal of sports medicine · 2023 · Fat (adipose) tissue · reports side effects
  70. Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial.Stem cell research & therapy · 2023 · Fat (adipose) tissue
  71. Effects of platelet-rich plasma on subchondral bone marrow edema and biomarkers in synovial fluid of knee osteoarthritis.The Knee · 2023 · Platelet-rich plasma · reports side effects
  72. Is the Combination of Platelet-Rich Plasma and Hyaluronic Acid the Best Injective Treatment for Grade II-III Knee Osteoarthritis? A Prospective Study.Advances in orthopedics · 2023 · Platelet-rich plasma · reports side effects
  73. Outcome of Intra-articular Injection of Total Stromal Cells and Platelet-Rich Plasma in Primary Knee Osteoarthritis: A Randomized Clinical Trial.Cureus · 2023 · More than one source
  74. Clinical phase I/II trial of SVF therapy for cartilage regeneration: A cellular therapy with novel 3D MRI imaging for evaluating chondral defect of knee osteoarthritis.Frontiers in cell and developmental biology · 2023 · Fat (adipose) tissue
  75. A Randomized Trial of Intra-articular Injection Therapy for Knee Osteoarthritis.Investigative radiology · 2023 · More than one source
  76. Comparison of clinical outcome, cartilage turnover, and inflammatory activity following either intra-articular or a combination of intra-articular with intra-osseous platelet-rich plasma injections in osteoarthritis knee: A randomized, clinical trial.Injury · 2023 · Platelet-rich plasma
  77. Micro-fragmented adipose tissue (mFAT) associated with arthroscopic debridement provides functional improvement in knee osteoarthritis: a randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023 · Fat (adipose) tissue
  78. Autologous microfragmented adipose tissue and leukocyte-poor platelet-rich plasma combined with hyaluronic acid show comparable clinical outcomes for symptomatic early knee osteoarthritis over a two-year follow-up period: a prospective randomized clinical trial.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023 · More than one source · reports side effects
  79. Evaluation of the effect of intra-articular platelet-rich plasma and hyaluronic acid injections on femoral cartilage thickness in chronic knee osteoarthritis.Acta orthopaedica Belgica · 2022 · More than one source
  80. Carboplasty, a Simple Tibial Marrow Technique for Knee Osteoarthritis: A Placebo-Controlled Randomized Trial.Orthopaedic journal of sports medicine · 2022 · Bone marrow · reports side effects
  81. Assessment of the effectiveness and satisfaction of platelet-rich plasma compared with hyaluronic acid in knee osteoarthritis at minimum 7-year follow-up: A post hoc analysis of a randomized controlled trial.Frontiers in bioengineering and biotechnology · 2022 · Platelet-rich plasma · reports side effects
  82. An Open-Labeled Randomized Prospective Multi-center Study to Evaluate the Efficacy and Safety of Intra-articular Injection of OSSINEXT™, an Autologous Growth Factor Concentrate (AGFC) Compared to Hyaluronic Acid (HA) in Knee Osteoarthritis.Cureus · 2022 · Platelet-rich plasma · reports side effects
  83. Comparing efficacy of a single intraarticular injection of platelet-rich plasma (PRP) combined with different hyaluronans for knee osteoarthritis: a randomized-controlled clinical trial.BMC musculoskeletal disorders · 2022 · Platelet-rich plasma · reports side effects
  84. Double-Blind Randomized Controlled Trial Comparing Platelet-Rich Plasma With Intra-Articular Corticosteroid Injections in Patients With Bilateral Knee Osteoarthritis.Cureus · 2022 · Platelet-rich plasma
  85. Randomized control trial of mesenchymal stem cells versus hyaluronic acid in patients with knee osteoarthritis - A Hong Kong pilot study.Journal of orthopaedic translation · 2022 · Bone marrow
  86. Platelet-Rich Plasma Versus Microfragmented Adipose Tissue for Knee Osteoarthritis: A Randomized Controlled Trial.Orthopaedic journal of sports medicine · 2022 · More than one source
  87. Efficacy Evaluation of the Combined Platelet-Rich Plasma and Hyaluronic Acid after Arthroscopic Joint Debridement in Treating Knee Osteoarthritis.Scanning · 2022 · Platelet-rich plasma · reports side effects
  88. Clinical benefit of high tibial osteotomy combined with the intervention of platelet-rich plasma for severe knee osteoarthritis.Journal of orthopaedic surgery and research · 2022 · Platelet-rich plasma
  89. Comparing the Efficacy of Intra-Articular Single Platelet-Rich Plasma(PRP) versus Novel Crosslinked Hyaluronic Acid for Early-Stage Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2022 · More than one source
  90. A Comparative Study of Osteoarthritis Knee Arthroscopy versus Intra-Articular Platelet Rich Plasma Injection: A Randomised Study.Malaysian orthopaedic journal · 2022 · Platelet-rich plasma
  91. Microfragmented Adipose Tissue Versus Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Prospective Randomized Controlled Trial at 2-Year Follow-up.The American journal of sports medicine · 2022 · More than one source · reports side effects
  92. Efficacy of a Novel Intra-Articular Administration of Platelet-Rich Plasma One-Week Prior to Hyaluronic Acid versus Platelet-Rich Plasma Alone in Knee Osteoarthritis: A Prospective, Randomized, Double-Blind, Controlled Trial.Journal of clinical medicine · 2022 · Platelet-rich plasma
  93. Intra-articular Injection of Mesenchymal Stem Cells After High Tibial Osteotomy in Osteoarthritic Knee: Two-Year Follow-up of Randomized Control Trial.Stem cells translational medicine · 2022 · Fat (adipose) tissue · reports side effects
  94. The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial.The bone & joint journal · 2022 · Platelet-rich plasma
  95. Intra-Articular Injection of Platelet-Rich Plasma Is More Effective than Hyaluronic Acid or Steroid Injection in the Treatment of Mild to Moderate Knee Osteoarthritis: A Prospective, Randomized, Triple-Parallel Clinical Trial.Biomedicines · 2022 · Platelet-rich plasma
  96. Amniotic dehydrated cell and protein concentrate versus corticosteroid in knee osteoarthritis: preliminary findings.Regenerative medicine · 2022 · Umbilical cord and birth tissue
  97. Intra-articular injection with platelet-rich plasma compared to triamcinolone hexacetonide or saline solution in knee osteoarthritis: A double blinded randomized controlled trial with one year follow-up.Clinical rehabilitation · 2022 · Platelet-rich plasma
  98. Clinical Effect of Bushen Huoxue Method Combined with Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis and Its Effect on IL-1, IL-6, VEGF, and PGE-2.Journal of healthcare engineering · 2022 · Platelet-rich plasma
  99. Intra-Articular Injections of Autologous Adipose Tissue or Platelet-Rich Plasma Comparably Improve Clinical and Functional Outcomes in Patients with Knee Osteoarthritis.Biomedicines · 2022 · More than one source
  100. Bone Marrow Aspirate Concentrate Is Equivalent to Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis at 2 Years: A Prospective Randomized Trial.The American journal of sports medicine · 2022 · More than one source
  101. Mid-term prognosis of the stromal vascular fraction for knee osteoarthritis: a minimum 5-year follow-up study.Stem cell research & therapy · 2022 · Fat (adipose) tissue
  102. Intra-articular injections of platelet-rich plasma decrease pain and improve functional outcomes than sham saline in patients with knee osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022 · Platelet-rich plasma
  103. The Effect of Autologous Adipose-Derived Stromal Vascular Fractions on Cartilage Regeneration Was Quantitatively Evaluated Based on the 3D-FS-SPGR Sequence: A Clinical Trial Study.BioMed research international · 2022 · Fat (adipose) tissue · reports side effects
  104. Leukocyte-Rich versus Leukocyte-Poor Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Trial.The American journal of sports medicine · 2022 · Platelet-rich plasma · reports side effects
  105. Single intra-articular injection with or without intra-osseous injections of platelet-rich plasma in the treatment of osteoarthritis knee: A single-blind, randomized clinical trial.Injury · 2022 · Platelet-rich plasma · reports side effects
  106. Bone marrow aspirate concentrate injections provide similar results versus viscosupplementation up to 24 months of follow-up in patients with symptomatic knee osteoarthritis. A randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022 · Bone marrow · reports side effects
  107. Multiple platelet-rich plasma injections are superior to single PRP injections or saline in osteoarthritis of the knee: the 2-year results of a randomized, double-blind, placebo-controlled clinical trial.Archives of orthopaedic and trauma surgery · 2022 · Platelet-rich plasma
  108. Intra-articular Pure Platelet-Rich Plasma Combined With Open-Wedge High Tibial Osteotomy Improves Clinical Outcomes and Minimal Joint Space Width Compared With High Tibial Osteotomy Alone in Knee Osteoarthritis: A Prospective Study.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2022 · Platelet-rich plasma
  109. Intra-articular Infiltration of Platelet-Rich Plasma versus Hyaluronic Acid in Patients with Primary Knee Osteoarthritis: Preliminary Results from a Randomized Clinical Trial.Revista brasileira de ortopedia · 2022 · Platelet-rich plasma · reports side effects
  110. Intra-articular injection of Platelet rich plasma versus Hyaluronic acid for moderate knee osteoarthritis. A prospective, double-blind randomized controlled trial on 189 patients with follow-up for three years.Acta orthopaedica Belgica · 2021 · Platelet-rich plasma
  111. Single versus multi-dose intra-articular injection of platelet rich plasma in early stages of osteoarthritis of the knee: A single-blind, randomized, superiority trial.Archives of rheumatology · 2021 · Platelet-rich plasma · reports side effects
  112. Bone Marrow Aspirate Concentrate versus Platelet Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis.Medicina (Kaunas, Lithuania) · 2021 · More than one source · reports side effects
  113. Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial.JAMA · 2021 · Platelet-rich plasma
  114. Treatment of knee osteoarthritis with intra-articular injection of allogeneic adipose-derived stem cells (ADSCs) ELIXCYTE®: a phase I/II, randomized, active-control, single-blind, multiple-center clinical trial.Stem cell research & therapy · 2021 · Fat (adipose) tissue · reports side effects
  115. Efficacy of platelet-rich plasma and plasma for symptomatic treatment of knee osteoarthritis: a double-blinded placebo-controlled randomized clinical trial.BMC musculoskeletal disorders · 2021 · Platelet-rich plasma · reports side effects
  116. A Single-Blinded Randomized Controlled Trial of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee with Active Control.Journal of stem cells & regenerative medicine · 2021 · Bone marrow
  117. A Prospective Study Comparing Leukocyte-Poor Platelet-Rich Plasma Combined with Hyaluronic Acid and Autologous Microfragmented Adipose Tissue in Patients with Early Knee Osteoarthritis.Stem cells and development · 2021 · More than one source
  118. Intra-Articular Injection of Autologous Microfat and Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Comparative Study.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2021 · More than one source
  119. Using intra-articular allogenic lyophilized growth factors in primary knee osteoarthritis: a randomized pilot study.Regenerative medicine · 2021 · Source not stated · reports side effects
  120. Efficacy of Genicular Nerve Radiofrequency Ablation Versus Intra-Articular Platelet Rich Plasma in Chronic Knee Osteoarthritis: A Single-Blind Randomized Clinical Trial.Pain physician · 2021 · Platelet-rich plasma
  121. Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy.Scientific reports · 2021 · Platelet-rich plasma
  122. The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial.BMC musculoskeletal disorders · 2021 · Platelet-rich plasma
  123. Clinical Efficacy of Platelet-Rich Plasma Injection and Its Association With Growth Factors in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial As Compared With Hyaluronic Acid.The American journal of sports medicine · 2021 · Platelet-rich plasma · reports side effects
  124. Randomized, Placebo-Controlled Analysis of the Knee Synovial Environment Following Platelet-Rich Plasma Treatment for Knee Osteoarthritis.PM & R : the journal of injury, function, and rehabilitation · 2021 · Platelet-rich plasma
  125. Comparing efficacy of intraarticular single crosslinked Hyaluronan (HYAJOINT Plus) and platelet-rich plasma (PRP) versus PRP alone for treating knee osteoarthritis.Scientific reports · 2021 · Platelet-rich plasma · reports side effects
  126. Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2021 · Platelet-rich plasma · reports side effects
  127. Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis: what better postpone knee arthroplasty at fifteen years? A randomized study.International orthopaedics · 2021 · Bone marrow
  128. Human bone marrow mesenchymal stem cell injection in subchondral lesions of knee osteoarthritis: a prospective randomized study versus contralateral arthroplasty at a mean fifteen year follow-up.International orthopaedics · 2021 · Bone marrow
  129. Comparative Effect between Infiltration of Platelet-rich Plasma and the Use of Corticosteroids in the Treatment of Knee Osteoarthritis: A Prospective and Randomized Clinical Trial.Revista brasileira de ortopedia · 2020 · Platelet-rich plasma
  130. Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich plasma for the treatment of knee osteoarthritis.Journal of translational medicine · 2020 · Bone marrow · reports side effects
  131. Platelet-Rich Plasma-Derived Growth Factor vs Hyaluronic Acid Injection in the Individuals with Knee Osteoarthritis: A One Year Randomized Clinical Trial.Journal of pain research · 2020 · Platelet-rich plasma
  132. Clinical comparison of platelet-rich plasma injection and daily celecoxib administration in the treatment of early knee osteoarthritis: A randomized clinical trial.Journal of applied biomedicine · 2020 · Platelet-rich plasma
  133. Intra-articular platelet-rich plasma vs corticosteroids in the treatment of moderate knee osteoarthritis: a single-center prospective randomized controlled study with a 1-year follow up.Journal of orthopaedic surgery and research · 2020 · Platelet-rich plasma · reports side effects
  134. Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial.Iranian journal of allergy, asthma, and immunology · 2020 · More than one source
  135. Comparison of the short-term results of single-dose intra-articular peptide with hyaluronic acid and platelet-rich plasma injections in knee osteoarthritis: a randomized study.Clinical rheumatology · 2020 · More than one source
  136. Bone Marrow Aspirate Concentrate Is Equivalent to Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis at 1 Year: A Prospective, Randomized Trial.Orthopaedic journal of sports medicine · 2020 · More than one source
  137. Clinical Efficacy of Intra-articular Mesenchymal Stromal Cells for the Treatment of Knee Osteoarthritis: A Double-Blinded Prospective Randomized Controlled Clinical Trial.The American journal of sports medicine · 2020 · Fat (adipose) tissue · reports side effects
  138. Comparison of two platelet rich plasma formulations with viscosupplementation in treatment of moderate grade gonarthrosis: A prospective randomized controlled study.Journal of orthopaedics · 2020 · Platelet-rich plasma · reports side effects
  139. MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial).Journal of pain research · 2020 · Platelet-rich plasma
  140. Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020 · Bone marrow
  141. Implantation of mesenchymal stem cells in combination with allogenic cartilage improves cartilage regeneration and clinical outcomes in patients with concomitant high tibial osteotomy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020 · Source not stated
  142. The efficiency of platelet-rich plasma treatment in patients with knee osteoarthritis.Journal of back and musculoskeletal rehabilitation · 2020 · Platelet-rich plasma
  143. Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial.World journal of orthopedics · 2019 · Platelet-rich plasma · reports side effects
  144. Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study.Acta reumatologica portuguesa · 2019 · Platelet-rich plasma
  145. Treatment of knee osteoarthritis with intra-articular injection of autologous adipose-derived mesenchymal progenitor cells: a prospective, randomized, double-blind, active-controlled, phase IIb clinical trial.Stem cell research & therapy · 2019 · Fat (adipose) tissue · reports side effects
  146. Patient-reported health outcomes for severe knee osteoarthritis after conservative treatment with an intra-articular cell-free formulation for articular cartilage regeneration combined with usual medical care vs. usual medical care alone: A randomized controlled trial.Experimental and therapeutic medicine · 2019 · Source not stated · reports side effects
  147. Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial.Stem cells translational medicine · 2019 · Fat (adipose) tissue · reports side effects
  148. Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial.Regenerative medicine · 2019 · Fat (adipose) tissue · reports side effects
  149. Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled study.Der Orthopade · 2019 · Platelet-rich plasma
  150. Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2019 · Platelet-rich plasma
  151. Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial.Stem cells translational medicine · 2019 · Umbilical cord and birth tissue · reports side effects
  152. Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial.The American journal of sports medicine · 2019 · Platelet-rich plasma
  153. Safety and efficacy of allogenic placental mesenchymal stem cells for treating knee osteoarthritis: a pilot study.Cytotherapy · 2019 · Umbilical cord and birth tissue · reports side effects
  154. Quantitative T2 MRI Mapping and 12-Month Follow-up in a Randomized, Blinded, Placebo Controlled Trial of Bone Marrow Aspiration and Concentration for Osteoarthritis of the Knees.Cartilage · 2019 · Bone marrow
  155. Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial.International orthopaedics · 2019 · Fat (adipose) tissue · reports side effects
  156. Evaluation of the use of autologous micro-fragmented adipose tissue in the treatment of knee osteoarthritis: preliminary results of a randomized controlled trial.Journal of biological regulators and homeostatic agents · 2018 · Fat (adipose) tissue · reports side effects
  157. A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomized controlled trial with 2 year follow-up.Journal of translational medicine · 2018 · More than one source · reports side effects
  158. A phase I-II controlled randomized trial using a promising novel cell-free formulation for articular cartilage regeneration as treatment of severe osteoarthritis of the knee.European journal of medical research · 2018 · Source not stated · reports side effects
  159. Intra-articular implantation of autologous bone marrow-derived mesenchymal stromal cells to treat knee osteoarthritis: a randomized, triple-blind, placebo-controlled phase 1/2 clinical trial.Cytotherapy · 2018 · Bone marrow · reports side effects
  160. Clinical therapy of hyaluronic acid combined with platelet-rich plasma for the treatment of knee osteoarthritis.Experimental and therapeutic medicine · 2018 · More than one source · reports side effects
  161. Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2018 · Platelet-rich plasma
  162. Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II).Journal of translational medicine · 2018 · Bone marrow · reports side effects
  163. Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritis.International journal of rheumatic diseases · 2018 · Platelet-rich plasma
  164. Platelet-rich plasma shows beneficial effects for patients with knee osteoarthritis by suppressing inflammatory factors.Experimental and therapeutic medicine · 2018 · Platelet-rich plasma · reports side effects
  165. Intra-articular injections of expanded mesenchymal stem cells with and without addition of platelet-rich plasma are safe and effective for knee osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018 · Bone marrow · reports side effects
  166. Safety, tolerability and efficacy of intra-articular Progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study.Journal of translational medicine · 2018 · Fat (adipose) tissue · reports side effects
  167. Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis.Clinical rheumatology · 2018 · Platelet-rich plasma
  168. The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis.Clinical interventions in aging · 2018 · Platelet-rich plasma
  169. Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2018 · Platelet-rich plasma
  170. Effects of Platelet-Rich Plasma on Pain and Muscle Strength in Patients With Knee Osteoarthritis.American journal of physical medicine & rehabilitation · 2018 · Platelet-rich plasma
  171. Comparison of Efficiency Between Corticosteroid and Platelet Rich Plasma Injection Therapies in Patients With Knee Osteoarthritis.Archives of rheumatology · 2018 · Platelet-rich plasma
  172. Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid. A randomized controlled trial.Clinical rehabilitation · 2018 · Platelet-rich plasma · reports side effects
  173. Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF) Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2017 · Platelet-rich plasma · reports side effects
  174. Safety, tolerability, clinical, and joint structural outcomes of a single intra-articular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction: a controlled double-blind randomised trial.Arthritis research & therapy · 2017 · Source not stated · reports side effects
  175. Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical Trial.Orthopaedic journal of sports medicine · 2017 · Platelet-rich plasma
  176. Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis.The American journal of sports medicine · 2017 · Platelet-rich plasma
  177. A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis.The American journal of sports medicine · 2017 · Bone marrow · reports side effects
  178. Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017 · Platelet-rich plasma
  179. Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017 · Platelet-rich plasma
  180. Adding Intra-Articular Growth Hormone to Platelet Rich Plasma under Ultrasound Guidance in Knee Osteoarthritis: A Comparative Double-Blind Clinical Trial.Anesthesiology and pain medicine · 2016 · Platelet-rich plasma · reports side effects
  181. Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee.Journal of stem cells & regenerative medicine · 2016 · More than one source
  182. Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®): preclinical and clinical trial in osteoarthritis of the knee joint.Arthritis research & therapy · 2016 · Bone marrow · reports side effects
  183. Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II).Journal of translational medicine · 2016 · Bone marrow · reports side effects
  184. Leukocyte-poor platelet-rich plasma is more effective than the conventional therapy with acetaminophen for the treatment of early knee osteoarthritis.Archives of orthopaedic and trauma surgery · 2016 · Platelet-rich plasma
  185. Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System.International journal of molecular sciences · 2016 · Platelet-rich plasma
  186. Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study.BMC musculoskeletal disorders · 2016 · Platelet-rich plasma · reports side effects
  187. Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis: An FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial.The American journal of sports medicine · 2016 · Platelet-rich plasma · reports side effects
  188. Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial.The Journal of sports medicine and physical fitness · 2016 · Platelet-rich plasma
  189. Effectiveness of platelet-rich plasma in the treatment of moderate knee osteoarthritis: a randomized prospective study.Journal of physical therapy science · 2015 · Platelet-rich plasma
  190. Treatment of knee osteoarthritis with platelet-rich plasma in comparison with transcutaneous electrical nerve stimulation plus exercise: a randomized clinical trial.Medical journal of the Islamic Republic of Iran · 2015 · Platelet-rich plasma
  191. Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation: A Randomized Controlled Trial.The American journal of sports medicine · 2015 · Platelet-rich plasma · reports side effects
  192. Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial.Transplantation · 2015 · Bone marrow
  193. Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial).Clinical medicine insights. Arthritis and musculoskeletal disorders · 2015 · Platelet-rich plasma
  194. The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015 · Platelet-rich plasma
  195. Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial.Orthopedic reviews · 2014 · Platelet-rich plasma
  196. Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years' follow-up.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2013 · Bone marrow
  197. Is platelet-rich plasma able to enhance the results of arthroscopic microfracture in early osteoarthritis and cartilage lesion over 40 years of age?European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2013 · Platelet-rich plasma
  198. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial.The American journal of sports medicine · 2013 · Platelet-rich plasma · reports side effects
  199. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial.BMC musculoskeletal disorders · 2012 · Platelet-rich plasma · reports side effects
  200. Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis.The American journal of sports medicine · 2012 · Platelet-rich plasma

Data last updated September 28, 2026. Searched 1,979 PubMed records and 358 ClinicalTrials.gov records. How we sort studies.